Protein Details: Aquaporin Z
Protein ID
ICDB_Pro_1239
Protein Name
Aquaporin Z
Gene Name
aqpZ; BR2001; BS1330_I1995
Organism
Brucella suis biovar 1 (strain 1330)
Length
228 amino acids
AlphaFoldDB
AF-Q8FY85-F1-model_v4.pdb
Function
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Sequence
MLNKLSAEFFGTFWLVFGGCGSAILAAAFPELGIGFLGVALAFGLTVLTMAYAVGGISGGHFNPAVSLSLTVAGRLPAKDLIPYWVAQVLGAIATAAILYVIASGKDGFSAGGLASNGYGELSPGGYSMMAGLLIEIILTAFFIIIILGSTSSLAPAGFAPIAIGFGLTLIHLVSIPVTNTSVNPARSTGVALFADTAALSQLWLFWVAPLVGAVIGAIIWKGLLGRD
PDB Structures
Ligand Binding
Binding Site
SITE 20: "Involved in tetramerization or stability of the tetramer"; SITE 43: "Selectivity filter"; SITE 172: "Selectivity filter"; SITE 181: "Selectivity filter"; SITE 187: "Selectivity filter"
Disease
Location
DOI ID
10.1073/pnas.192319099; 10.1128/jb.06181-11
RefSeq
WP_006190978.1